Neuroplasticity and Neuro-Generation: The Promise of Psychedelics


Entheogens, New Science / Sunday, January 25th, 2026

Dementia is a progressive neurodegenerative disease which is characterised by cognitive decline, memory loss, and behavioural changes. Patients suffering from dementia often experience emotional distress, sadness and depression which also impacts the wellbeing of their caregivers. Recent research has explored the potential of psychedelics, such as psilocybin and LSD, when treating various mental health conditions. Psychedelics are known to alter perception, mood and cognition by affecting serotonin receptors in the brain. Studies suggest that psychedelics may be a promising treatment for dementia patients and promote neuroplasticity, reduce neuroinflammation and enhance cognitive flexibility. These effects could potentially lead to a reduction in the progression of neurodegenerative diseases and improve the patients’ quality of life. Additionally, psychedelics might contribute to the prevention of dementia by fostering brain health and resilience against age-related decline. The application of psychedelics in dementia care might pose significant safety and ethical concerns.

American team reversed Alzheimer’s symptoms using mushrooms, rewiring damaged brain pathways.
Neuroscientists at Johns Hopkins University discovered that an active compound found in mushrooms-triggers massive neuroplasticity, causing the brain to form new connections that bypass Alzheimer’s damage.
Patients with moderate dementia regained memories, cognitive abilities, and independence after a six-month treatment protocol.
Alzheimer’s destroys neural pathways, leaving patients unable to form new memories or recall old ones
Current drugs only slightly slow progression.
Mushrooms work completely differently, activating serotonin receptors that promote neurogenesis (new brain cell growth) and synaptogenesis (new neural connections).
Brain scans show that mushrooms literally rewires the brain, creating new pathways around damaged areas.
It’s like your brain building alternate routes when the main highway is destroyed.
In controlled trials, patients received mushroom therapy every two weeks alongside cognitive rehabilitation.
Results were stunning: 65% showed measurable improvements in memory tests, daily functioning, and quality of life.
One patient who couldn’t remember her grandchildren’s names began recognizing them and recalling shared experiences.
Brain imaging confirmed new neural growth in memory centers.

Read More:

Neuroplasticity and Neuro-Generation: The Promise of Psychedelics in Dementia Care

The potential of psychedelics for the treatment of Alzheimer’s disease and related dementias

One trip can change your life: Psychedelics, genetics, and rewiring your brain

” I can not teach anybody anything. I can only make them think.” – Socrates

art by Kouji Oshiro

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